Vitamin E succinate Basic information |
Product Name: | Vitamin E succinate |
Synonyms: | 1210IU D-α-Tocopherol succinate,vitamin E succinate 1185IU D-α-Tocopherol succinate,vitamin E succinate;(+)-α-TOCOPHEROL ACID SUCCINATE;D-α-Tocopheryl succinate, Ph. Eur.;[2theta-[2theta(4theta,8theta)]]-cyl)-2h-1-benzopyran-6-yl]este;alpha-tocopherol,succinate;alpha-tocopherolhemisuccinate;butanedioicacid,mono(3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltride;butanedioicacid,mono[3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltride |
CAS: | 4345-03-3 |
MF: | C33H54O5 |
MW: | 530.78 |
EINECS: | 224-403-8 |
Product Categories: | Vitamins and derivatives;Vitamin Ingredients;Aromatics;Chiral Reagents;Heterocycles;1185IU/1210IU;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol File: | 4345-03-3.mol |
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Vitamin E succinate Chemical Properties |
Melting point | ~76 °C(lit.) |
Boiling point | 625.8±55.0 °C(Predicted) |
density | 1.002±0.06 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | Practically insoluble in water, very soluble in methylene chloride, soluble in and in anhydrous ethanol. |
form | neat |
pka | 4.35±0.17(Predicted) |
λmax | 286nm(EtOH)(lit.) |
Merck | 14,9495 |
BRN | 4038233 |
CAS DataBase Reference | 4345-03-3(CAS DataBase Reference) |
EPA Substance Registry System | D-.alpha.-Tocopheryl acid succinate (4345-03-3) |
Safety Information |
WGK Germany | 1 |
RTECS | EJ9984000 |
F | 8-10-23 |
HS Code | 2936280000 |
Toxicity | LD50 oral in rat: > 7gm/kg |
MSDS Information |
Provider | Language |
---|---|
D-alpha-Tocopherol succinate | English |
SigmaAldrich | English |
Vitamin E succinate Usage And Synthesis |
Chemical Properties | Off-White to Pale Yellow Solid |
Uses | A potent antioxidant tocopherol |
Uses | A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines. |
General Description | White powder. |
Air & Water Reactions | Insoluble in water. |
Reactivity Profile | Vitamin E succinate is an ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides. |
Fire Hazard | Flash point data for Vitamin E succinate are not available; however, Vitamin E succinate is probably combustible. |
Safety Profile | When heated to decomposition it emits acrid smoke and irritating fumes. |