L-Citrulline Basic information |
Product Name: | L-Citrulline |
Synonyms: | Ibuprofen Impurity 78;Arginine Impurity 2(Arginine EP Impurity B)(Citrulline);L-CTRULLINE;L-Citrullne;Arginine EP Impurity B;n5-(aminocarbonyl)-l-ornithin;N5-(aminocarbonyl)-L-Ornithine;ALPHA-AMINO-DELTA-UREIDO-N-VALERIC ACID |
CAS: | 372-75-8 |
MF: | C6H13N3O3 |
MW: | 175.19 |
EINECS: | 206-759-6 |
Product Categories: | Amino Acids;Citruline [Cit];Amino Acids;Unusual Amino Acids;Biochemistry;non-Proteinorganic Amino Acids;Nutritional Supplements;L-Amino Acids;Aliphatics;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol File: | 372-75-8.mol |
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L-Citrulline Chemical Properties |
Melting point | 214 °C |
alpha | 25.5 º (c=8, 6N HCl) |
Boiling point | 306.48°C (rough estimate) |
density | 1.2919 (rough estimate) |
refractive index | 26 ° (C=8, 6mol/L HCl) |
storage temp. | Store at 0-5°C |
pka | 2.43(at 25℃) |
form | Crystals or Crystalline Powder |
color | White |
Odor | Odorless |
Water Solubility | 200 g/L (20 ºC) |
Merck | 14,2331 |
BRN | 6055157 |
InChIKey | RHGKLRLOHDJJDR-BYPYZUCNSA-N |
CAS DataBase Reference | 372-75-8(CAS DataBase Reference) |
EPA Substance Registry System | L-Ornithine, N5-(aminocarbonyl)- (372-75-8) |
Safety Information |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 24/25-36-26 |
WGK Germany | 3 |
TSCA | Yes |
HS Code | 29241900 |
MSDS Information |
Provider | Language |
---|---|
L(+)-2-Amino-5-ureidovaleric acid | English |
ACROS | English |
SigmaAldrich | English |
ALFA | English |
L-Citrulline Usage And Synthesis |
Chemical Properties | White powder |
Originator | StaminO2,ErgoPharm |
Uses | An amino acid, L-Citrulline can be used in the treatment of asthenia and as an essential intermediate in the biosynthesis of nitric oxide. |
Uses | An essential intermediate in the biosynthesis of nitric oxide. |
Manufacturing Process | Citrulline is obtained as a result of a reaction of L-arginine hydrochloride with sodium hydroxide, copper oxide and hydrogen sulfide. In practice it is usually used as malate salt |
Therapeutic Function | Stimulant, Detoxicant |
Purification Methods | Likely impurities are arginine and ornithine. Crystallise S-citrulline from water by adding 5 volumes of EtOH. Also crystallise it from water by addition of MeOH. [Ellenbogen J Am Chem Soc 74 5198 1952, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2491-2494 1961, Beilstein 4 IV 2647.] |
L-Citrulline Preparation Products And Raw materials |
Raw materials | Hydroxide |