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| 4-Hydroxy Chemical Properties |
| Melting point |
148-151 °C (lit.) |
| Boiling point |
234.6°C (rough estimate) |
| density |
1.2143 (rough estimate) |
| refractive index |
1.4945 (estimate) |
| storage temp. |
Store below +30°C. |
| solubility |
50g/l |
| pka |
4.50±0.10(Predicted) |
| form |
Crystalline Powder |
| color |
White to cream or light tan |
| PH |
2.0-2.4 (30g/l, H2O, 20℃) |
| Water Solubility |
Soluble in dimethyl sulfoxide and methanol. Slightly soluble in water. |
| BRN |
1448766 |
| InChIKey |
XQXPVVBIMDBYFF-UHFFFAOYSA-N |
| CAS DataBase Reference |
156-38-7(CAS DataBase Reference) |
| NIST Chemistry Reference |
Benzeneacetic acid, 4-hydroxy-(156-38-7) |
| EPA Substance Registry System |
Benzeneacetic acid, 4-hydroxy- (156-38-7) |
| Hazard Codes |
Xi |
| Risk Statements |
36/37/38 |
| Safety Statements |
26-36-24/25 |
| WGK Germany |
3 |
| RTECS |
AI2680000 |
| Hazard Note |
Irritant |
| TSCA |
Yes |
| HS Code |
29182990 |
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| 4-Hydroxy Usage And Synthesis |
| Description |
4-Hydroxy is an acetate derivative used in the acylation of phenols and amines1. It is an active component of Chinese herb Aster tataricus which had been widely used in China for the treatment of pulmonary diseases, HBV, and carcinoma. It is an active metabolite of amino acid metabolism. Study has also shown that it can attenuate inflammation and edema through suppressing hypertonic and hypoxic induction of HIF-1α in seawater aspiration-induced lung injury in rats. In chemical industry, it is an intermediate used to synthesize atenolol and 3, 4-dihydroxy. |
| Referrence |
- Liu, Zhongyang, et al. "4-Hydroxy Attenuated Inflammation and Edema via Suppressing HIF-1α in Seawater Aspiration-Induced Lung Injury in Rats." International Journal of Molecular Sciences 15.7(2014):12861-84.
- Ng, T.B.; Liu, F.; Lu, Y.; Cheng, C.H.; Wang, Z. Antioxidant activity of compounds from the medicinal herb Aster tataricus. Comp. Biochem. Physiol. 2003, 136, 109–115.
- Du, L.; Mei, H.F.; Yin, X.; Xing, Y.Q. Delayed growth of glioma by a polysaccharide from Aster tataricus involve upregulation of Bax/Bcl-2 ratio, activation of caspase-3/8/9, and downregulation of the Akt. Tumour Biol. 2014, 35, 1819–1825.
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| Chemical Properties |
white to cream or light tan crystalline powder |
| Uses |
A compound present in olive oil. An important fine chemical intermediate with broad prospects for application development. |
| Definition |
ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 4-hydroxyphenyl group. |
| Purification Methods |
Crystallise the acid from water or Et2O/pet r. The p-bromophenacyl ester has m 117o (from EtOH). [Beilstein 10 II 112, 10 III 430, 10 IV 543.] |
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| 4-Hydroxy Preparation Products And Raw materials |
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