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| Benzimidazole Basic information |
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| Benzimidazole Chemical Properties |
| Melting point |
169-171 °C (lit.) |
| Boiling point |
360 °C |
| density |
1.1151 (rough estimate) |
| refractive index |
1.5500 (estimate) |
| Fp |
360°C |
| storage temp. |
Store below +30°C. |
| solubility |
xylene: soluble1g in 2g (boiling)(lit.) |
| pka |
5.532(at 25℃) |
| form |
Crystalline Powder or Crystals |
| color |
Beige to brown |
| Water Solubility |
sparingly soluble |
| λmax |
271nm(MeOH)(lit.) |
| Merck |
14,1081 |
| BRN |
109682 |
| Stability: |
Stable. Combustible. Incompatible with strong oxidising agents. |
| InChIKey |
HYZJCKYKOHLVJF-UHFFFAOYSA-N |
| CAS DataBase Reference |
51-17-2(CAS DataBase Reference) |
| NIST Chemistry Reference |
1H-Benzimidazole(51-17-2) |
| EPA Substance Registry System |
Benzimidazole (51-17-2) |
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| Benzimidazole Usage And Synthesis |
| Chemical Properties |
white crystals |
| Uses |
Usually used as template compound in the preparation of molecularly imprinted polymer via electropolymerization and electrodeposition of pyrrole on a pencil graphite electrode,and also used in the preparation of benzimidazolium surfactant, 1-hexadecyl-1H-benzimidazole. |
| General Description |
White tabular crystals. |
| Air & Water Reactions |
Insoluble in water. |
| Reactivity Profile |
An amine. Neutralizes acids to form salts plus water. These acid-base reactions are exothermic. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated in combination with strong reducing agents, such as hydrides. May be shock sensitive. |
| Health Hazard |
ACUTE/CHRONIC HAZARDS: When heated to decomposition Benzimidazole emits highly toxic fumes. |
| Fire Hazard |
Flash point data for Benzimidazole are not available. Benzimidazole is probably combustible. |
| Pharmacology |
The mode of action of benzimidazoles has been described in several comprehensive reviews (1,32,33). The primary mode of action of benzimidazoles has been identified as the specific binding to the β-subunit of fungal tubulin and, consequently, an interference with microtubule assembly. Microtubules are major components of the fungal cytoskeleton and are involved in meiosis and mitosis, both of which are blocked in the presence of benzimidazoles. |
| Safety Profile |
Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Mutation data reported. When heated to decomposition it emits highly toxic fumes of NOx. |
| Purification Methods |
It crystallises from water or aqueous EtOH (charcoal) and is dried at 100o for 12hours. [Beilstein 23 H 131, 23/6 V 196.] |
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| Benzimidazole Preparation Products And Raw materials |
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