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The World Largest Manufacturer Factory Supply CROSCARMELLOSE SODIUM CAS 74811-65-7

The World Largest Manufacturer Factory Supply CROSCARMELLOSE SODIUM CAS 74811-65-7

Products - High Quality-Cosmetic & Daily Chemicals Ingredients-3500MT/Year
  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    1KG/Tin 25KG/Drum*Carton
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    info@leader-biogroup.com
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    25KGS
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

The World Largest Manufacturer Factory Supply CROSCARMELLOSE SODIUM CAS 74811-65-7

  • The World Largest Manufacturer Factory Supply CROSCARMELLOSE SODIUM CAS 74811-65-7
  • The World Largest Manufacturer Factory Supply CROSCARMELLOSE SODIUM CAS 74811-65-7
  • The World Largest Manufacturer Factory Supply CROSCARMELLOSE SODIUM CAS 74811-65-7
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Product Name: CROSCARMELLOSE SODIUM
Synonyms: Sodiumcroscarmellose;CROSCARMELLOSE SODIUM;MODIFIED CELLULOSE GUM;PRIMELLOSE(R);Crosscarmelosesodium;Croscarmellose natrium;Cross-linked carboxymethylcellulose sodium;Unii-m28ol1hh48
CAS: 74811-65-7
MF: Null
MW: 0
EINECS: 1312995-182-4
Product Categories:  
Mol File: Mol File
 
 
CROSCARMELLOSE SODIUM Chemical Properties
density Bulk density (g/cc) 0.48
solubility Practically insoluble in , in anhydrous ethanol and in toluene.
EPA Substance Registry System Croscarmellose sodium (74811-65-7)
 
 
CROSCARMELLOSE SODIUM Usage And Synthesis
Chemical Properties pH 5.0-7.0 tablet disintegrant.
Chemical Properties Croscarmellose sodium occurs as an odorless, white or grayishwhite powder.
Uses Packaged under nitrogen
Uses antimicrobial
Uses Used as Disintegrant in Capsules, Tablet and Granule Formulations.
Uses Pharmaceutic aid (tablet disintegrant).
Production Methods Alkali cellulose is prepared by steeping cellulose, obtained from wood pulp or cotton fibers, in sodium hydroxide solution. The alkali cellulose is then reacted with sodium monochloroacetate to obtain carboxymethylcellulose sodium. After the substitution reaction is completed and all of the sodium hydroxide has been used, the excess sodium monochloroacetate slowly hydrolyzes to glycolic acid. The glycolic acid changes a few of the sodium carboxymethyl groups to the free acid and catalyzes the formation ofcrosslinkstoproducecroscarmellosesodium.Thecroscarmellose sodium is then extracted with aqueous alcohol and any remaining sodium chloride or sodium glycolate is removed. After purification, croscarmellose sodium of purity greater than 99.5% is obtained. The croscarmellose sodium may be milled to break the polymer fibers into shorter lengths and hence improve its flow properties.
Brand name Ac-Di-Sol (FMC); CLD 2 (Buckeye).
Pharmaceutical Applications Croscarmellose sodium is used in oral pharmaceutical formulations as a disintegrant for capsules,tablets, and granules.
In tablet formulations, croscarmellose sodium may be used in bothdirect-compressionandwet-granulationprocesses.Whenused in wet granulations, the croscarmellose sodium should be added in both the wet and dry stages of the process (intra- and extragranularly) so that the wicking and swelling ability of the disintegrant is best utilized. Croscarmellose sodium at concentrations up to 5% w/w may be used as a tablet disintegrant, although normally 2% w/w is used in tablets prepared by direct compression and 3% w/w in tablets prepared by a wet-granulation process.
Safety Croscarmellose sodium is mainly used as a disintegrant in oral pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material. However, oral consumption of large amounts of croscarmellose sodium may have a laxative effect, although the quantities used in solid dosage formulations are unlikely to cause such problems.
In the UK, croscarmellose sodium is accepted for use in dietary supplements.
The WHO has not specified an acceptable daily intake for the related substance carboxymethylcellulose sodium, used as a food additive, since the levels necessary to achieve a desired effect were not considered sufficient to be a hazard to health.
storage Croscarmellose sodium is a stable though hygroscopic material.
A model tablet formulation prepared by direct compression, withcroscarmellosesodiumasadisintegrant,showednosignificant differenceindrugdissolutionafterstorageat30°Cfor14months.
Croscarmellose sodium should be stored in a well-closed container in a cool, dry place.
Incompatibilities The efficacy of disintegrants, such as croscarmellose sodium, may be slightly reduced in tablet formulations prepared by either the wet-granulation or direct-compression process that contain hygroscopic excipients such as sorbitol.
Croscarmellose sodium is not compatible with strong acids or with soluble salts of iron and some other metals such as aluminum, mercury, and zinc.
Regulatory Status Included in the FDA Inactive Ingredients Database (oral capsules, granules, sublingual tablets, and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
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