| 18-Crown-6 Basic information |
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| 18-Crown-6 Chemical Properties |
| Melting point |
42-45 °C(lit.) |
| Boiling point |
116°C 0,2mm |
| density |
1,175 g/cm3 |
| refractive index |
1.4580 (estimate) |
| Fp |
>230 °F |
| storage temp. |
Store at 0-5°C |
| form |
Crystals or Crystalline Mass or Liquid |
| color |
White or clear colorless |
| Water Solubility |
SOLUBLE |
| Sensitive |
Hygroscopic |
| Merck |
14,2602 |
| BRN |
1619616 |
| Stability: |
Stable. Incompatible with strong acids, strong oxidizing agents. |
| InChIKey |
XEZNGIUYQVAUSS-UHFFFAOYSA-N |
| CAS DataBase Reference |
17455-13-9(CAS DataBase Reference) |
| NIST Chemistry Reference |
1,4,7,10,13,16-Hexaoxacyclooctadecane(17455-13-9) |
| EPA Substance Registry System |
1,4,7,10,13,16-Hexaoxacyclooctadecane (17455-13-9) |
| Hazard Codes |
Xn,Xi |
| Risk Statements |
22-36/37/38-36-20/22-20/21/22 |
| Safety Statements |
26-36-39 |
| RIDADR |
2811 |
| WGK Germany |
3 |
| RTECS |
MP4500000 |
| F |
10 |
| TSCA |
Yes |
| HazardClass |
6.1(b) |
| PackingGroup |
III |
| HS Code |
29329995 |
| Toxicity |
LD50 orally in Rabbit: 525 mg/kg LD50 dermal Rabbit 3888 mg/kg |
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| 18-Crown-6 Usage And Synthesis |
| Chemical Properties |
slightly yellow solid |
| Uses |
A useful phase transfer catalyst. |
| Synthesis Reference(s) |
The Journal of Organic Chemistry, 39, p. 2445, 1974 DOI: 10.1021/jo00930a037 |
| Purification Methods |
Recrystallise it from acetonitrile and dry it in a vacuum. Purify it also by precipitating the 18-crown-6/nitromethane 1:2 complex with Et2O/nitromethane (10:1 mixture). The complex is decomposed in vacuum whereby 18-crown-6 distils off under the reduced pressure. [Beilstein 19/12 V 601.] |
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| 18-Crown-6 Preparation Products And Raw materials |
| Raw materials |
POTASSIUM CYANIDE-->Alkali Metals, plasma standard solution, Specpure, Ba,Be,Ca,Cs,K,Li,Mg,Na,Rb,Sr, 100μg/ml-->15-Crown-5-->GLOBULINS, CAT GAMMA |
| Preparation Products |
1,1'-DIMETHYLFERROCENE-->N,N-Dimethylethylenediamine-->5-Bromoindazole-->3-PHENOXYPHENYLACETONITRILE-->1,3-THIAZOLIDIN-2-ONE-->Cefpodoxime proxetil-->1,2-EPOXYCYCLODODECANE-->2,4-DIAMINO-6-FLUOROPYRIMIDINE-->[(2-OXO-2H-CHROMEN-7-YL)OXY]ACETIC ACID-->3-AMINO-2-FLUORO-4-PICOLINE-->5-AMINOMETHYL-PYRROLIDIN-2-ONE-->2-AMINO-4,6-DIFLUOROPYRIMIDINE-->2-(4-BROMOPHENYL)THIOPHENE-->4-AMINO-2,6-DIFLUOROPYRIMIDINE-->N,N,N',N'-Tetraphenylbenzidine |
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