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2-Phenylacetamide Basic information |
Uses |
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2-Phenylacetamide Chemical Properties |
Hazard Codes |
Xi |
Risk Statements |
22-36 |
Safety Statements |
22-24/25-60-36-26 |
RTECS |
AC7705000 |
Hazard Note |
Irritant |
TSCA |
Yes |
HazardClass |
IRRITANT |
HS Code |
29242990 |
Toxicity |
LD50 ipr-mus: 430 mg/kg PCJOAU 10,579,76 |
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2-Phenylacetamide Usage And Synthesis |
Uses |
2-Phenylacetamide is used as a pharmaceutical intermediate. |
Chemical Properties |
White crystalline |
Uses |
In manufacture of penicillin G. |
Definition |
ChEBI: A monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. |
Synthesis Reference(s) |
Journal of the American Chemical Society, 75, p. 740, 1953 DOI: 10.1021/ja01099a504
The Journal of Organic Chemistry, 43, p. 402, 1978 DOI: 10.1021/jo00397a005
Organic Syntheses, Coll. Vol. 4, p. 760, 1963 |
Safety Profile |
Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx. |
Purification Methods |
Crystallise the acetamide repeatedly from absolute EtOH, EtOAc (m 160-161o) or H2O (m 159-160o). Dry it in vacuo over P2O5. [Beilstein 9 H 347, 9 III 2193, 9 IV 1632.] |
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2-Phenylacetamide Preparation Products And Raw materials |
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