| Ferrous gluconate Basic information |
| Product Name: |
Ferrous gluconate |
| Synonyms: |
irox(gador);nionate;ray-gluciron;iron digluconate;Ferrous Gluconate NF, Powder;Ferrous Gluconate USP/FCC, Granular;Ferrous Gluconate(CIQ);Ferrous Gluconate, Granular |
| CAS: |
299-29-6 |
| MF: |
C12H20FeO14 |
| MW: |
444.12 |
| EINECS: |
206-076-3 |
| Product Categories: |
Organometallics;Food additive |
| Mol File: |
299-29-6.mol |
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| Ferrous gluconate Chemical Properties |
| density |
0.79[at 20℃] |
| vapor pressure |
2.399hPa at 10℃ |
| solubility |
Freely but slowly soluble in water giving a greenish-brown solution, more readily soluble in hot water, practically insoluble in ethanol (96 per cent). |
| pka |
6.28[at 20 ℃] |
| Odor |
at 100.00?%. caramellic |
| Water Solubility |
118g/L at 25℃ |
| Stability: |
May be light-sensitive - store in the dark. |
| LogP |
-2.6 at 25℃ |
| CAS DataBase Reference |
299-29-6(CAS DataBase Reference) |
| EPA Substance Registry System |
Iron, bis(D-gluconato-.kappa.O1,.kappa.O2)- (299-29-6) |
| Safety Statements |
22-24/25 |
| WGK Germany |
2 |
| RTECS |
LZ5150000 |
| Hazardous Substances Data |
299-29-6(Hazardous Substances Data) |
| Toxicity |
child,TDLo,oral,162mg/kg (162mg/kg),GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"GASTROINTESTINAL: NAUSEA OR VOMITING,JAMA, Journal of the American Medical Association. Vol. 218, Pg. 1179, 1971. |
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| Ferrous gluconate Usage And Synthesis |
| Chemical Properties |
Ferrous Gluconate is a yellow-gray or light green-yellow fine powder or granules with a slightly caramel-like smell. Soluble in water (10g/100mg warm water), almost insoluble in ethanol. The 5% aqueous solution is acidic to litmus, and the aqueous solution can be stabilized by adding glucose. |
| Uses |
Ferrous Gluconate is a nutrient and dietary supplement that is a source of iron and a coloring adjunct. it is a yellowish gray to pale greenish yellow powder or granules with a burnt sugar odor. it has a solubility of 1 g in approximately 10 ml of water with slight heating. it is used by the pharmaceutical industry as an iron supplement in vitamin pills. it is used by olive growers to darken the olives to a uniform black color. it can function as an iron fortifier in corn and soy products, breakfast cereals, beverages, and dietary foods. |
| Preparation |
Ferrous gluconate is prepared from barium gluconate and iron sulfate. |
| Biological Functions |
Ferrous Gluconate is a form of mineral iron for oral administration, Ferrous Gluconate is absorbed in the stomach and small intestine and combines with apoferritin to form ferritin, which is stored in the liver, spleen, red bone marrow, and intestinal mucosa. Important in transport of oxygen by hemoglobin to the tissues, iron is also found in myoglobin, transferrin, and ferritin, and is as a component of many enzymes such as catalase, peroxidase, and cytochromes. (NCI04) |
| General Description |
Ferrous Gluconate is an iron mineral salt used in iron and multivitamin supplements. It is used to treat or prevent iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body). |
| Flammability and Explosibility |
Non flammable |
| Safety Profile |
Poison by intraperitoneal and intravenous routes. Moderately toxic by ingestion. Human systemic effects by ingestion: hypermothty, diarrhea, nausea, and vomiting. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. When heated to decomposition it emits acrid smoke and irritating fumes. |
| Drug interactions |
Potentially hazardous interactions with other drugs
Antibacterials: reduced absorption of 4-quinolones and tetracyclines.
Dimercaprol: avoid concomitant use.
Mycophenolate: may significantly reduce absorption of mycophenolate. |
| Metabolism |
Following absorption, the majority of iron is bound to transferrin and transported to the bone marrow where it is incorporated into haemoglobin. The remainder is stored within ferritin or haemosiderin or is incorporated into myoglobin with smaller amounts occurring in haemcontaining enzymes or in plasma bound to transferrin. Only very small amounts are excreted as the body reabsorbs the iron after the haemoglobin has broken down. |
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