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China Manufacturer Supply High Quality FERULIC ACID ETHYL ESTER/ETHYL FERULATE/Ethyl 4-hydroxy-3-methoxycinnamate CAS 4046-02-0

China Manufacturer Supply High Quality FERULIC ACID ETHYL ESTER/ETHYL FERULATE/Ethyl 4-hydroxy-3-methoxycinnamate CAS 4046-02-0

Products - High Quality-Cosmetic & Daily Chemicals Ingredients-3500MT/Year
  • Purity
    99.9%
  • Use
    Health Care
  • Origin
    China
  • Package
    25KG/Drum
  • Manufacturer
    XI'AN LEADER BIOCHEMICAL ENGINEERING CO.,LTD
  • Place of Origin
    CHINA
  • Brand Name
    info@leader-biogroup.com
  • Certification
    ISO,GMP,SGS,HALA,KOSER,HACCP
  • Model Number
    LD
  • Minimum Order Quantity
    1KG
  • Price
    Negotiate Depend on order quantity
  • Packaging Details
    25KG/Drum
  • Delivery Time
    2-3 working days
  • Payment Terms
    Western Union, MoneyGram, T/T, L/C
  • Supply Ability
    10MTS/Month

China Manufacturer Supply High Quality FERULIC ACID ETHYL ESTER/ETHYL FERULATE/Ethyl 4-hydroxy-3-methoxycinnamate CAS 4046-02-0

  • China Manufacturer Supply High Quality FERULIC ACID ETHYL ESTER/ETHYL FERULATE/Ethyl 4-hydroxy-3-methoxycinnamate CAS 4046-02-0
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Ethyl 4-hydroxy-3-methoxycinnamate Basic information

FERULIC ACID ETHYL ESTER/ETHYL FERULATE/Ethyl 4-hydroxy-3-methoxycinnamate

Ethyl Ferulate Description

Ethyl ferulate is an ester of the powerful antioxidant ferulic acid and ethyl alcohol. Much like its parent acid, ethyl ferulate functions as an antioxidant, helping to neutralize the impact of external aggressors that contribute to signs of aging and is particularly adept at supporting skin’s defenses when exposed to UV light. This particular benefit is why ethyl ferulate is often incorporated into sunscreens.

Further research has shown that ethyl ferulate can help soothe skin in the face of environmental stressors, like UV rays and pollution, when added to creams and lotions.

Although ethyl ferulate is most commonly created for the purpose of cosmetic use through synthetic esterification, it can also be isolated from rice bran oil. As a raw material, it often appears as a creamy white powder or as granules of the same color.

In cosmetic formulations, it’s most often found between concentrations of 0.5% and 1%. Toxicity testing has confirmed the safety of this ingredient.
Product Name: FERULIC ACID ETHYL ESTER/ETHYL FERULATE/Ethyl 4-hydroxy-3-methoxycinnamate
Synonyms: ETHYL 4-HYDROXY-3-METHOXYCINNAMATE;Ethyl 3-(4-hydroxy-3-l)acrylate;ETHYL TRANS-3-(4'-HYDROXY-3'-ACRYLATE;ETHYL FERULATE;FERULIC ACID ETHYL ESTER;BUTTPARK 1214-55;4-HYDROXY-3-METHOXYCINNAMIC ACID ETHYL ESTER;RARECHEM AL BI 0735
CAS: 4046-02-0
MF: C12H14O4
MW: 222.24
EINECS: 223-745-5
Product Categories: Building Blocks;C12 to C63;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks;Aromatic Esters;Cinnamic acid;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Inhibitors
Mol File: 4046-02-0.mol
Ethyl 4-hydroxy-3-methoxycinnamate Structure
 
Ethyl 4-hydroxy-3-methoxycinnamate Chemical Properties
Melting point 63-65 °C(lit.)
Boiling point 164-166 °C0.5 mm Hg(lit.)
density 1.0643 (rough estimate)
refractive index 1.4560 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform (Slightly), Ethyl Acetate (Slightly)
form Solid
pka 8.88±0.18(Predicted)
color White to Off-White
Sensitive Light Sensitive
BRN 2696807
Stability: Hygroscopic, Light Sensitive
InChIKey ATJVZXXHKSYELS-FNORWQNLSA-N
LogP 1.940 (est)
CAS DataBase Reference 4046-02-0(CAS DataBase Reference)
NIST Chemistry Reference ethyl ferulate(4046-02-0)
 
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39-36
WGK Germany 3
Hazard Note Irritant
HS Code 29189900
MSDS Information
Provider Language
SigmaAldrich English
ALFA English
 
Ethyl 4-hydroxy-3-methoxycinnamate Usage And Synthesis
Description Ferulic acid is a hydroxycinnamic acid that is abundant in plants and originally derived from giant fennel (F. communis). This naturally-occurring phenolic has antioxidant activities that provide protection against inflammation and cancer. Ferulic acid ethyl ester is a lipophilic derivative of ferulic acid, demonstrating increased ability to cross cell membranes. Ferulic acid ethyl ester has less antioxidant capacity than ferulic acid in neuronal PC12 cells (IC50 = 66.7 μM for ferulic acid ethyl ester vs. 44.6 μM for ferulic acid, 2,2-diphenyl-1-picrylhydrazyl radical scavenging). However, ferulic acid ethyl ester increases the expression of heme oxygenase-1, Hsp70, and Hsp72, providing neuroprotection against amyloid β-peptide. Moreover, ferulic acid ethyl ester (25 μM) completely prevents cytotoxicity induced by ultraviolet B irradiation of normal human epidermal melanocytes, again associated with an induced expression of heme oxygenase-1 and Hsp70.
Uses Ferulic acid ethyl ester is an ethyl ester derivative of Ferulic acid (F308900), which is used as an antioxidant and food preservative.
Synthesis To an ice-chilled suspension of trans-ferulic acid (1.942 g, 10 mmol, 1 eq) in absolute ethanol (20 mL) was added thionyl chloride (0.87 mL, 12 mmol, 1.2 eq). The resulting mixture was refluxed with stirring for 20 h. The solution was concentrated in vacuo, dissolved in ethyl acetate (30 mL) and washed with a 1 M HCI solution (15 mL), saturated NaHCOs solution (15 mL) and brine (15 mL). The organic layer was dried over anhydrous NajSC and concentrated in vacuo to afford Ethyl 4-hydroxy-3-methoxycinnamate as an orange oil (2.185 g, yield: 98%).
Ethyl 4'-hydroxy-3'-methoxycinnamate
 
 

 

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