Bekanamycin Basic information |
Product Name: |
Bekanamycin |
Synonyms: |
d-streptamine,o-3-amino-3-deoxy-alpha-d-glucopyranosyl-(1-4)-o-(2,6-diamino-2,;kanendomycin;kdm;nebramycinfactor5;nebramycinv;(2R,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-[(1R,2S,3S,4R,6S)-4,6-diamino-3-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxyoxane-3,4-diol;Bekanamycin;NK 1006 |
CAS: |
4696-76-8 |
MF: |
C18H37N5O10 |
MW: |
483.51 |
EINECS: |
225-170-5 |
Product Categories: |
Inhibitors;Pharmaceutical Intermediates;API |
Mol File: |
4696-76-8.mol |
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Bekanamycin Chemical Properties |
Melting point |
178-182° (dec) |
alpha |
D18 +130° (c = 0.5 in water); D21 +114° (c = 0.98 in water) |
Boiling point |
580.49°C (rough estimate) |
density |
1.3771 (rough estimate) |
refractive index |
1.7600 (estimate) |
storage temp. |
under inert gas (nitrogen or Argon) at 2–8 °C |
solubility |
Aqueous Acid (Slightly), Methanol (Slightly, Heated, Sonicated) |
form |
Solid |
pka |
13.07±0.70(Predicted) |
color |
Crystals |
Stability: |
Hygroscopic |
Toxicity |
LD50 i.v. in mice: 136 mg/kg (Wakazawa) |
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Bekanamycin Usage And Synthesis |
Description |
Bekanamycin, kanamycin B, was found in the culture broth of Streptomyces kanamyceticus by Umezawa et al. in 1957. It shows the same antibacterial spectrum as kanamycin but with stronger activity. The total synthesis of bekanamycin was completed by Umezawa et al. in 1968 and the knowledge gained from its synthesis was successfully applied to the synthesis of dibekacin. |
Originator |
Kanendomycin,Meiji Seika,Japan,1969 |
Uses |
Kanamycin B (cas# 4696-76-8) is a compound useful in organic synthesis. |
Definition |
ChEBI: Kanamycin B is a member of kanamycins. It is a conjugate base of a kanamycin B(5+). |
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