2-Ketoglutaric acid Basic information |
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2-Ketoglutaric acid Chemical Properties |
Melting point |
113-115 °C |
Boiling point |
185.67°C (rough estimate) |
density |
1.2821 (rough estimate) |
vapor pressure |
0.01Pa at 25℃ |
refractive index |
1.3920 (estimate) |
FEMA |
3891 | 2-OXOPENTANEDIOIC ACID |
storage temp. |
2-8°C |
solubility |
H2O: soluble0.1g/mL, clear, colorless |
form |
Crystalline Powder |
pka |
2.47(at 25℃) |
color |
White to slightly yellow |
Odor |
Odorless |
PH |
3.09(1 mM solution);2.36(10 mM solution);1.77(100 mM solution) |
Water Solubility |
Soluble in water, methanol and dimethyl sulfoxide. |
Merck |
14,5303 |
JECFA Number |
634 |
BRN |
1705689 |
InChIKey |
KPGXRSRHYNQIFN-UHFFFAOYSA-N |
LogP |
-2.08 at 25℃ |
CAS DataBase Reference |
328-50-7(CAS DataBase Reference) |
NIST Chemistry Reference |
2-Oxopentanedioic acid(328-50-7) |
EPA Substance Registry System |
Pentanedioic acid, 2-oxo- (328-50-7) |
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2-Ketoglutaric acid Usage And Synthesis |
Description |
2-Ketoglutaric acid also known as α-Ketoglutaric acid (AKG) is a chemical found in the body. It is a ketone derivative of the organic compound glutaric acid. It is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid or Krebs cycle. In combination with L-glutamate, AKG can reduce levels of ammonia formed in the brain, muscles, and kidneys, as well as help balance the body’s nitrogen chemistry and prevent nitrogen excess in body tissues and fluids.
α-Ketoglutaric acid is used for kidney disease; intestinal and stomach disorders, including bacterial infections; liver problems; cataracts; and recurring yeast infections. It is also used for improving the way kidney patients receiving hemodialysis treatments process protein. |
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