LEADER BIOCHEMICAL GROUP
Inquiry: info@leader-biogroup.com
Hot Line: +86-029-68895030
+86-029-68569962
Fax : +86-029-68569961
Sodium ketoisocaproate Basic information |
Product Name: |
Sodium ketoisocaproate |
Synonyms: |
Sodium ketoisocaproate;SODIUM 4-METHYL-2-OXOVALERATE;SODIUM ALPHA-KETOISOCAPRATE;2-KETOISOCAPROIC ACID SODIUM SALT;2-KETOISOHEXANOIC ACID SODIUM SALT;A-KETOISOCAPROIC ACID, SODIUM SALT;ALPHA-KETOISOCAPROIC ACID SODIUM SALT;4-Methyl-2-oxopentanoic acid monosodium salt |
CAS: |
4502-00-5 |
MF: |
C6H9NaO3 |
MW: |
152.12 |
EINECS: |
224-816-3 |
Product Categories: |
pharmacetical |
Mol File: |
4502-00-5.mol |
 |
|
Sodium ketoisocaproate Chemical Properties |
Safety Statements |
24/25-22 |
WGK Germany |
3 |
|
Sodium ketoisocaproate Usage And Synthesis |
Occurrence |
Reported found in banana, asparagus, cheese, white wine, a, blue cheese and provolone cheese. |
Uses |
Sodium 4-methyl-2-oxovalerate has been used for quantifying branched-chain keto acids from cell extracts by HPLC-fluorescence method. |
Uses |
4-Methyl-2-oxovaleric Acid is an α-ketomonocarboxylic acid that triggers insulin release by acting upon receptor sites which differ from those occupied by amino acids. 4-Methyl-2-oxovaleric Acid is an intermediate in the metabolism of Leucine. |
Biochem/physiol Actions |
α-Ketoisocaproic acid is a leucine metabolite that is known to induce insulin secretion from the βcells of pancreas. Enteral infusion of aα-Ketoisocaproate is found to ameliorate, endotoxemic condition. The resulting ketone bodies obtained from its conversion, might serve as an energy source. Accumulation of α-Ketoisocaproic acid is characterized in branched chain ketoaciduria, which is caused due to the lack of branched chain L-2-keto acid dehydrogenase activity. α-Ketoisocaproic acid causes dissociation in the oxidative phosphorylation reaction and acts as a metabolic inhibitor of α-ketoglutarate dehydrogenase. Thus, leads to a defect in the mitochondrial homeostasis, observed in branched chain ketoaciduria. |
|
Sodium ketoisocaproate Preparation Products And Raw materials |
  |